David Worthington studied at the Art Students League in New York and worked at PS1 Studios in Queens, New York before reading Philosophy and Theology at Oxford University. After this he spent two years doing a Foundation Degree at Byam Shaw School of Art, London. He then moved to Barcelona where he studied at Massana School of Art and Belles Artes, Barcelona University. In 1992, Worthington returned to New York to the New York Studio School. In 2000, Worthington read an MA in Visual Culture at Middlesex University. From 1993-5 he was the resident artist at Llorens Artigas Foundation, Barcelona.
Worthington has exhibited all over the world, including Japan, but most of his work has been shown in London. He was one of Three Sculptors at the London Business School in 1996. He took part in various exhibitions at the Lefevre Gallery, London between 1997 and 2002, including his first solo exhibition in 1999. He had a subsequent solo show there in 2001/2 and was the invited sculptor at Glyndebourne Festival in 2001. He has his work in public collections, including a commission in Kobe, Japan. He has also exhibited with Basel Miami Beach at the Crane Kalman Gallery.
Worthington uses various materials including bronze, tarmac, cement paint and wax but is passionate about stone. In 2003 took part in Live Culture at Tate Modern, a performance work with Guillermo Gomez Pena. However, he remains committed to object making and says "each generation must define itself through its creations, including objects".